EMD-75289

Single-particle
3.0 Å
EMD-75289
3D View Gallery
Deposition: 27/01/2026
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75289
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 10ml summary report (pdf.gz) Map and 10ml FULL report (pdf.gz)
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AAP-SO2 bound Open Mtb-EC: Cryo-EM structure of Mtb RNAP elongation complex (substrate loading mimic) with an open active site (open TL and RH-FL)

EMD-75289

Single-particle
3.0 Å
EMD-75289
3D View Gallery
Deposition: 27/01/2026
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mycobacterium tuberculosis, Escherichia coli
Sample: AAP-SO2 bound Open Mtb-EC: Cryo-EM structure of Mtb RNAP elongation complex (substrate loading mimic)
Fitted models: 10ml

Deposition Authors: Dhingra Y, Darst SA
RNA polymerase inhibitors reveal active-site motions essential for the nucleotide-addition cycle.
Dhingra Y, Landick R, Campbell EA, Darst SA
(2026) bioRxiv
PUBMED: 41993335
DOI: doi:10.64898/2026.04.06.716786
ISSN: 2692-8205