EMD-74513
E. coli RNA polymerase elongation complex containing the unnatural dP:Z*TP base pair in a trigger-loop-open conformation (a)
EMD-74513
Single-particle2.6 Å
Deposition: 16/12/2025Map released: 29/07/2026
Last modified: 16/09/2026
Sample Organism:
Escherichia coli
Sample: E. coli RNA polymerase elongation complex containing the unnatural dP:Z*TP base pair in a trigger-loop-open conformation (a).
Fitted models: 9zp1
Deposition Authors: Li Q
,
Benner SA
,
Wang D
Sample: E. coli RNA polymerase elongation complex containing the unnatural dP:Z*TP base pair in a trigger-loop-open conformation (a).
Fitted models: 9zp1
Deposition Authors: Li Q
,
Benner SA
,
Wang D
Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase.
Li Q
,
Kim HJ,
Liu Y,
Oh J,
Hou P,
Hoshika S,
Pintilie G,
Aiyer S,
Chong J,
Lyumkis D,
Benner SA
,
Wang D
(2026) Nat Commun , 17
,
Kim HJ,
Liu Y,
Oh J,
Hou P,
Hoshika S,
Pintilie G,
Aiyer S,
Chong J,
Lyumkis D,
Benner SA
,
Wang D
(2026) Nat Commun , 17
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM102362 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM148476 (United States)
- National Science Foundation (NSF, United States): MCB-2419300 (United States)
- National Science Foundation (NSF, United States): MCB-1939086 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 1R24GM154186 (United States)
