EMD-74364

Single-particle
2.32 Å
EMD-74364
3D View Gallery
Deposition: 05/12/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74364

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zkd summary report (pdf.gz) Map-9zkd FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Focused map of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking muscle fatigue)

EMD-74364

Single-particle
2.32 Å
EMD-74364
3D View Gallery
Deposition: 05/12/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus
Sample: RY12 domain of rabbit RyR1 complexed with ADP and Mg2+
Fitted models: 9zkd

Deposition Authors: Kim K, Clarke OB
Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene
Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB
(2026) Nat Commun
DOI: doi:10.1038/s41467-026-76519-y
ISSN: 2041-1723