EMD-74353

Single-particle
3.18 Å
EMD-74353
3D View Gallery
Deposition: 05/12/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74353

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zk8 summary report (pdf.gz) Map-9zk8 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking physiological conditions; bound and closed RY12)

EMD-74353

Single-particle
3.18 Å
EMD-74353
3D View Gallery
Deposition: 05/12/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus
Sample: RyR1 complexed with FKBP12.6 and calmodulin
Fitted models: 9zk8

Deposition Authors: Kim K, Clarke OB
Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene
Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB
(2026) Nat Commun
DOI: doi:10.1038/s41467-026-76519-y
ISSN: 2041-1723