EMD-74100

Single-particle
3.94 Å
EMD-74100
3D View Gallery
Deposition: 29/11/2025
Map released: 15/04/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74100

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zed summary report (pdf.gz) Map-9zed FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the endogenous U2/branchpoint spliceosomal complex (SF3A state 2)

EMD-74100

Single-particle
3.94 Å
EMD-74100
3D View Gallery
Deposition: 29/11/2025
Map released: 15/04/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Endogenous U2/branchpoint spliceosomal complex (SF3A state 2)
Fitted models: 9zed

Deposition Authors: Liu S, Su T, Zhou ZH
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing.
Liu S, Su T, Huang J, Lin CH, Black DL , Damianov A, Zhou ZH
(2026) bioRxiv
PUBMED: 41929118
DOI: doi:10.64898/2026.03.26.714623
ISSN: 2692-8205