EMD-73971

Single-particle
2.29 Å
EMD-73971
3D View Gallery
Deposition: 19/11/2025
Map released: 27/05/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73971

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zaw summary report (pdf.gz) Map-9zaw FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

HMG-CoA synthase 1 (HMGCS1) bound to inhibitor compound CNP7

EMD-73971

Single-particle
2.29 Å
EMD-73971
3D View Gallery
Deposition: 19/11/2025
Map released: 27/05/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) bound to inhibitor compound CNP7
Fitted models: 9zaw

Deposition Authors: An H, Sun L, de la Cruz MJ, Sen S
Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer.
Sun L, Yi SA, Pham BQ, Mocellin A, Sen S, de la Cruz MJ, Ordureau A, An H
(2026) J Am Chem Soc , 148 , 20705 - 20719
PUBMED: 42127206
DOI: doi:10.1021/jacs.6c02556
ISSN: 1520-5126
ASTM: JACSAT