EMD-73801

Single-particle
3.84 Å
EMD-73801
3D View Gallery
Deposition: 09/11/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73801

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9z4a summary report (pdf.gz) Map-9z4a FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the human PRMT5:MEP50:pICln complex at a 4:3:4 stoichiometric ratio

EMD-73801

Single-particle
3.84 Å
EMD-73801
3D View Gallery
Deposition: 09/11/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The PRMT5:MEP50:pICln complex at a 4:3:4 stoichiometric ratio
Fitted models: 9z4a

Deposition Authors: Xu X, Chi Z, Jiang W, Li C
Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment.
Chi Z, Xu X, Shen Z, Deng X, Elzey BD, Li C, Jiang W, Hu CD
(2026) J Enzyme Inhib Med Chem , 41 , 2727844 - 2727844
PUBMED: 42710907
DOI: doi:10.1080/14756366.2026.2727844
ISSN: 1475-6374