EMD-73757

Single-particle
2.63 Å
EMD-73757
3D View Gallery
Deposition: 04/11/2025
Map released: 10/06/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73757

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9z1z summary report (pdf.gz) Map-9z1z FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 18 degrees Celsius (consensus)

EMD-73757

Single-particle
2.63 Å
EMD-73757
3D View Gallery
Deposition: 04/11/2025
Map released: 10/06/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human TRPM4 channel in complex with calcium and TPPO at 18 degrees Celsius
Fitted models: 9z1z

Deposition Authors: Hu J, Lu W, Du J
Temperature and intrinsic Ca 2+ reshape TRPM4 pharmacology.
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O'Dea G, Sheng J, Du J, Lu W
(2026) Nat Struct Mol Biol , 33 , 973 - 984
PUBMED: 42265346
DOI: doi:10.1038/s41594-026-01818-3
ISSN: 1545-9985