EMD-73754

Single-particle
2.86 Å
EMD-73754
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Deposition: 04/11/2025
Map released: 10/06/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73754
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9z1w summary report (pdf.gz) Map and 9z1w FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 37 degrees Celsius (consensus)

EMD-73754

Single-particle
2.86 Å
EMD-73754
3D View Gallery
Deposition: 04/11/2025
Map released: 10/06/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human TRPM4 channel in complex with calcium and TPPO at 37 degrees Celsius
Fitted models: 9z1w

Deposition Authors: Jinhong H, Wei L, Juan D
Temperature and intrinsic Ca 2+ reshape TRPM4 pharmacology.
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O'Dea G, Sheng J, Du J, Lu W
(2026) Nat Struct Mol Biol , 33 , 973 - 984
PUBMED: 42265346
DOI: doi:10.1038/s41594-026-01818-3
ISSN: 1545-9985