EMD-73644
AI-generated RNA-guided nuclease TAM-bound state
EMD-73644
Single-particle2.8 Å
Deposition: 29/10/2025Map released: 15/07/2026
Last modified: 29/07/2026
Sample Organism:
synthetic construct,
Deinococcus radiodurans
Sample: AI-designed RNA-guided nuclease TAM-bound state
Fitted models: 9yyg
Deposition Authors: Skopintsev P
,
Esain-Garcia I ,
Doudna J,
Doudna J
Sample: AI-designed RNA-guided nuclease TAM-bound state
Fitted models: 9yyg
Deposition Authors: Skopintsev P
,
Esain-Garcia I ,
Doudna J,
Doudna J
Structure and evolution-guided design of minimal RNA-guided nucleases.
Skopintsev P ,
Esain-Garcia I ,
DeTurk EC ,
Yoon PH ,
Zhou Z,
Weiss T ,
Kamalu M ,
Chamraj A ,
Loi KJ,
Langeberg CJ ,
Boger RS ,
Nisonoff H ,
Karp HM ,
Chen LX ,
Shi H ,
Vohra K,
Banfield JF ,
Cate JHD ,
Jacobsen SE ,
Doudna JA
(2026) Science , 393 , 313 - 318
,
Esain-Garcia I ,
DeTurk EC ,
Yoon PH ,
Zhou Z,
Weiss T ,
Kamalu M ,
Chamraj A ,
Loi KJ,
Langeberg CJ ,
Boger RS ,
Nisonoff H ,
Karp HM ,
Chen LX ,
Shi H ,
Vohra K,
Banfield JF ,
Cate JHD ,
Jacobsen SE ,
Doudna JA
(2026) Science , 393 , 313 - 318
Grant Support:
- National Science Foundation (NSF, United States): DGE 2334027 (United States)
- Swiss National Science Foundation: P500PB_214418 (Switzerland)