EMD-73531

Single-particle
2.81 Å
EMD-73531
3D View Gallery
Deposition: 23/10/2025
Map released: 01/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73531

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9yvp summary report (pdf.gz) Map-9yvp FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the L900V;R993P;S1060R mutant mouse TRPM4 channel in an open state bound to NC1 and PI(4,5)P2.

EMD-73531

Single-particle
2.81 Å
EMD-73531
3D View Gallery
Deposition: 23/10/2025
Map released: 01/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: mouse TRPM4
Fitted models: 9yvp

Deposition Authors: Teixeira-Duarte CM, Jiang Y
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload.
Teixeira-Duarte CM, Fu W, Zeng W, Wang J, Jiang X, Zhao Z, Zhong Q, Jiang Y
(2026) Nat Commun
PUBMED: 42342693
DOI: doi:10.1038/s41467-026-74814-2
ISSN: 2041-1723