EMD-73531

Single-particle
2.81 Å
EMD-73531
3D View Gallery
Deposition: 23/10/2025
Map released: 01/07/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73531
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yvp summary report (pdf.gz) Map and 9yvp FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the L900V;R993P;S1060R mutant mouse TRPM4 channel in an open state bound to NC1 and PI(4,5)P2.

EMD-73531

Single-particle
2.81 Å
EMD-73531
3D View Gallery
Deposition: 23/10/2025
Map released: 01/07/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: mouse TRPM4
Fitted models: 9yvp

Deposition Authors: Teixeira-Duarte CM, Jiang Y
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload.
Teixeira-Duarte CM, Fu W, Zeng W, Wang J, Jiang X, Zhao Z, Zhong Q, Jiang Y
(2026) bioRxiv
PUBMED: 41659621
DOI: doi:10.64898/2026.01.28.702369
ISSN: 2692-8205