EMD-73510

Single-particle
2.6 Å
EMD-73510
3D View Gallery
Deposition: 23/10/2025
Map released: 15/04/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73510
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yuz summary report (pdf.gz) Map and 9yuz FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the human 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.

EMD-73510

Single-particle
2.6 Å
EMD-73510
3D View Gallery
Deposition: 23/10/2025
Map released: 15/04/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human 20S proteasome
Fitted models: 9yuz

Deposition Authors: Yan NL, Gu X, Fajtova P, Tse E, Melo A, Southworth DR, O'Donoghue A, Sello JK, Gestwicki JE
An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome.
Gu X, Fajtova P, Yan NL, Saxena A, Fei F, Zhu J, Tse E, Melo A, Yoo E, Buchwald NH, Southworth DR, Bogyo M, Derisi JL, Gestwicki JE, O'Donoghue AJ, Sello JK
(2026) J Med Chem
PUBMED: 41921688
DOI: doi:10.1021/acs.jmedchem.5c03223
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: