EMD-73362

Single-particle
3.0 Å
EMD-73362
3D View Gallery
Deposition: 16/10/2025
Map released: 08/04/2026
Last modified: 20/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73362
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yr7 summary report (pdf.gz) Map and 9yr7 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state

EMD-73362

Single-particle
3.0 Å
EMD-73362
3D View Gallery
Deposition: 16/10/2025
Map released: 08/04/2026
Last modified: 20/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens, Aequorea victoria
Sample: Human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state
Fitted models: 9yr7

Deposition Authors: Somavarapu AK , Ge J , Yengo CM , Craig R , Padron R
Cryo-EM reveals how cardiomyopathy therapeutic drugs modulate the myosin motors of the heart.
Somavarapu AK , Ge J , Yengo CM , Craig R , Padron R
(2026) Sci Adv , 12 , eaed6472 - eaed6472
PUBMED: 42054467
DOI: doi:10.1126/sciadv.aed6472
ISSN: 2375-2548