EMD-72906

Single-particle
3.08 Å
EMD-72906
3D View Gallery
Deposition: 26/09/2025
Map released: 25/03/2026
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72906
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yfu summary report (pdf.gz) Map and 9yfu FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of GPR61 bound to inverse agonist compound 15

EMD-72906

Single-particle
3.08 Å
EMD-72906
3D View Gallery
Deposition: 26/09/2025
Map released: 25/03/2026
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Complex of GPR61 ICL3 BRIL fusion with Fab24 BAK5 and Fab hinge-binding nanobody bound to inverse agonist compound 15
Fitted models: 9yfu

Deposition Authors: Lees JA, Dias JM, Han S
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled Receptor.
Fisher EL, Dechert Schmitt AM, Tuttle JB, Unwalla R, Lovett GH, Kormos BL, Coffman KJ, Zhou D, Moran M, Williams J, Xiao J, LaChapelle EA, Fortin JP, Sheikh AQ, Stevens KA, Kong JX, Hughes EAG, Esquejo RM, Joaquim S, Amar NL, Archambault D, Garren J, Breen D, Jagarlapudi S, Dullea R, O'Connor RE, Koslov-Davino E, Callegari E, Dias JM, Lees JA, Borzilleri K, Han S, Brooks J, Vajdos FF, Goyal A, Zhang L, Zhang Y
(2026) J Med Chem
PUBMED: 41834467
DOI: doi:10.1021/acs.jmedchem.6c00081
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: