EMD-72906
Structure of GPR61 bound to inverse agonist compound 15
EMD-72906
Single-particle3.08 Å
Deposition: 26/09/2025Map released: 25/03/2026
Last modified: 01/04/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: Complex of GPR61 ICL3 BRIL fusion with Fab24 BAK5 and Fab hinge-binding nanobody bound to inverse agonist compound 15
Fitted models: 9yfu
Deposition Authors: Lees JA, Dias JM, Han S
Sample: Complex of GPR61 ICL3 BRIL fusion with Fab24 BAK5 and Fab hinge-binding nanobody bound to inverse agonist compound 15
Fitted models: 9yfu
Deposition Authors: Lees JA, Dias JM, Han S
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled Receptor.
Fisher EL 
,
Dechert Schmitt AM,
Tuttle JB ,
Unwalla R,
Lovett GH,
Kormos BL,
Coffman KJ,
Zhou D ,
Moran M,
Williams J,
Xiao J ,
LaChapelle EA,
Fortin JP,
Sheikh AQ,
Stevens KA,
Kong JX,
Hughes EAG ,
Esquejo RM ,
Joaquim S,
Amar NL,
Archambault D,
Garren J,
Breen D,
Jagarlapudi S,
Dullea R,
O'Connor RE,
Koslov-Davino E,
Callegari E,
Dias JM,
Lees JA,
Borzilleri K,
Han S,
Brooks J,
Vajdos FF,
Goyal A,
Zhang L ,
Zhang Y
(2026) J Med Chem , 69 , 7393 - 7404
,
Dechert Schmitt AM,
Tuttle JB ,
Unwalla R,
Lovett GH,
Kormos BL,
Coffman KJ,
Zhou D ,
Moran M,
Williams J,
Xiao J ,
LaChapelle EA,
Fortin JP,
Sheikh AQ,
Stevens KA,
Kong JX,
Hughes EAG ,
Esquejo RM ,
Joaquim S,
Amar NL,
Archambault D,
Garren J,
Breen D,
Jagarlapudi S,
Dullea R,
O'Connor RE,
Koslov-Davino E,
Callegari E,
Dias JM,
Lees JA,
Borzilleri K,
Han S,
Brooks J,
Vajdos FF,
Goyal A,
Zhang L ,
Zhang Y
(2026) J Med Chem , 69 , 7393 - 7404
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