EMD-72526

Single-particle
3.1 Å
EMD-72526
3D View Gallery
Deposition: 06/09/2025
Map released: 15/07/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72526

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y61 summary report (pdf.gz) Map-9y61 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of ternary complex NSD2-PWWP1:CRBN:DDB1 in complex with NSD2-LDD, an LDD degrader

EMD-72526

Single-particle
3.1 Å
EMD-72526
3D View Gallery
Deposition: 06/09/2025
Map released: 15/07/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex NSD2-PWWP1:NSD2-LDD:CRBN:DDB1
Fitted models: 9y61

Deposition Authors: Zhu J, Pagarigan BE, Fang W
NSD2 Degradation Remediates the Oncogenic Cistrome in t(4;14) Multiple Myeloma.
Hu B, Edwards J, Modi H, Gamez J, Echeagaray OE, Hess K, Ren Y, Anderson D, Larrayoz M, Zhu J, Johnson SA, Deb G, Jankeel D, Janardhanan P, Leisten J, Peng S, Christoforou A, Stong N, Fontanillo C, Bjorklund CC, Hagner PR, Gandhi AK, Martinez-Climent JA, Narla RK, Lopez-Girona A, Rolfe M, Bence N, Mortensen DS, Groocock L
(2026) Blood
PUBMED: 42371798
DOI: doi:10.1182/blood.2025031998
ISSN: 1528-0020
Grant Support: