EMD-72521

Single-particle
3.1 Å
EMD-72521
3D View Gallery
Deposition: 05/09/2025
Map released: 08/07/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72521
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9y5s summary report (pdf.gz) Map and 9y5s FULL report (pdf.gz)
EMICSS annotations (xml)

eIF2B lacking the latch helix bound to ISRACT-01 (Inactive state)

EMD-72521

Single-particle
3.1 Å
EMD-72521
3D View Gallery
Deposition: 05/09/2025
Map released: 08/07/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Eukaryotic translation initiation factor 2B (eIF2B) bound to ISRACT-01 in the I-state
Fitted models: 9y5s

Deposition Authors: Dalwadi U, Croll T, Subramanian A, Lee DJ, Arthur C, Walter P, Frost A
Allosteric disordering of eIF2B regulates the integrated stress response
Dalwadi U, Subramanian A, Deal A, Conrad JE, Nadjsombati T, Venkatesh M, Boone M, Egea PF, He L, Jain N, Lee DJ, Liu Y, Reineke LC, Saito K, Talledge N, Toutkoushian H, Le Vasseur M, Zappa F, de Groot RJ, Acosta-Alvear D, Arthur CP, Nunnari J, Marqusee S, Lawrence RE, Costa-Mattioli M, Crawford JJ, van Kuppeveld FJM, Croll TI, Walter P, Frost A
(2026) Nat Chem Biol
DOI: doi:10.1038/s41589-026-02256-4
ISSN: 1552-4469
Grant Support: