EMD-72520

Single-particle
3.01 Å
EMD-72520
3D View Gallery
Deposition: 05/09/2025
Map released: 08/07/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72520
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9y5r summary report (pdf.gz) Map and 9y5r FULL report (pdf.gz)
EMICSS annotations (xml)

Eukaryotic translation initiation factor 2-B (eIF2B) bound to phosphorylated eIF2alpha (NTD)

EMD-72520

Single-particle
3.01 Å
EMD-72520
3D View Gallery
Deposition: 05/09/2025
Map released: 08/07/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: eIF2B bound to phospho-eIF2alpha(S51P)
Fitted models: 9y5r

Deposition Authors: Dalwadi U, Croll T, Subramanian A, Lee DJ, Arthur C, Walter P, Frost A
Allosteric disordering of eIF2B regulates the integrated stress response
Dalwadi U, Subramanian A, Deal A, Conrad JE, Nadjsombati T, Venkatesh M, Boone M, Egea PF, He L, Jain N, Lee DJ, Liu Y, Reineke LC, Saito K, Talledge N, Toutkoushian H, Le Vasseur M, Zappa F, de Groot RJ, Acosta-Alvear D, Arthur CP, Nunnari J, Marqusee S, Lawrence RE, Costa-Mattioli M, Crawford JJ, van Kuppeveld FJM, Croll TI, Walter P, Frost A
(2026) Nat Chem Biol
DOI: doi:10.1038/s41589-026-02256-4
ISSN: 1552-4469
Grant Support: