EMD-72499

Single-particle
2.4 Å
EMD-72499
3D View Gallery
Deposition: 04/09/2025
Map released: 24/06/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72499

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y4w summary report (pdf.gz) Map-9y4w FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10 (CASP target)

EMD-72499

Single-particle
2.4 Å
EMD-72499
3D View Gallery
Deposition: 04/09/2025
Map released: 24/06/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Beluga whale coronavirus SW1
Sample: Eukaryotic translation initiation factor 2B bound to one copy of AcP10
Fitted models: 9y4w

Deposition Authors: Dalwadi U, Croll T, Subramanian A, Lee DJ, Arthur C, Walter P, Frost A
Allosteric disordering of eIF2B regulates the integrated stress response.
Dalwadi U, Subramanian A, Deal A, Conrad JE, Nadjsombati T, Venkatesh M, Boone M, Egea PF, He L, Jain N, Lee DJ, Liu Y, Reineke LC, Saito K, Talledge N, Toutkoushian H, Le Vasseur M, Zappa F, de Groot RJ, Acosta-Alvear D, Arthur CP, Nunnari J, Marqusee S, Lawrence RE, Costa-Mattioli M, Crawford JJ, van Kuppeveld FJM, Croll TI, Walter P, Frost A
(2026) Nat Chem Biol
PUBMED: 42373951
DOI: doi:10.1038/s41589-026-02256-4
ISSN: 1552-4469
Grant Support: