EMD-72485

Single-particle
2.96 Å
EMD-72485
3D View Gallery
Deposition: 03/09/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72485

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y4l summary report (pdf.gz) Map-9y4l FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM Structure of human MDA5 in complex with dsRNA (two protein subunits on dsRNA)

EMD-72485

Single-particle
2.96 Å
EMD-72485
3D View Gallery
Deposition: 03/09/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, in vitro transcription vector pT7-Fluc(deltai)
Sample: Complex of human MDA5 with dsRNA
Fitted models: 9y4l

Deposition Authors: Xu L, Chung K, Pyle A

Unraveling the molecular basis for MDA5 T331I disease-linked mutation
Xu L, Chung K, Guo R, Pan A, Pyle AM
To Be Published
Grant Support: