EMD-72467
Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state) (CASP target)
EMD-72467
Single-particle2.4 Å
Deposition: 02/09/2025Map released: 24/06/2026
Last modified: 15/07/2026
Sample Organism:
Homo sapiens
Sample: Eukaryotic translation initiation factor 2B
Fitted models: 9y3u
Deposition Authors: Dalwadi U
,
Croll T,
Subramanian A ,
Lee DJ ,
Arthur C,
Walter P ,
Frost A
Sample: Eukaryotic translation initiation factor 2B
Fitted models: 9y3u
Deposition Authors: Dalwadi U
,
Croll T,
Subramanian A ,
Lee DJ ,
Arthur C,
Walter P ,
Frost A
Allosteric disordering of eIF2B regulates the integrated stress response.
Dalwadi U ,
Subramanian A ,
Deal A ,
Conrad JE ,
Nadjsombati T ,
Venkatesh M,
Boone M ,
Egea PF ,
He L,
Jain N ,
Lee DJ ,
Liu Y,
Reineke LC,
Saito K,
Talledge N ,
Toutkoushian H,
Le Vasseur M ,
Zappa F,
de Groot RJ ,
Acosta-Alvear D ,
Arthur CP,
Nunnari J,
Marqusee S ,
Lawrence RE,
Costa-Mattioli M,
Crawford JJ ,
van Kuppeveld FJM ,
Croll TI ,
Walter P ,
Frost A
(2026) Nat Chem Biol
,
Subramanian A ,
Deal A ,
Conrad JE ,
Nadjsombati T ,
Venkatesh M,
Boone M ,
Egea PF ,
He L,
Jain N ,
Lee DJ ,
Liu Y,
Reineke LC,
Saito K,
Talledge N ,
Toutkoushian H,
Le Vasseur M ,
Zappa F,
de Groot RJ ,
Acosta-Alvear D ,
Arthur CP,
Nunnari J,
Marqusee S ,
Lawrence RE,
Costa-Mattioli M,
Crawford JJ ,
van Kuppeveld FJM ,
Croll TI ,
Walter P ,
Frost A
(2026) Nat Chem Biol
Grant Support:
- Other private: (United States)