EMD-72466

Single-particle
2.5 Å
EMD-72466
3D View Gallery
Deposition: 02/09/2025
Map released: 24/06/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72466

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y3t summary report (pdf.gz) Map-9y3t FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) (CASP target)

EMD-72466

Single-particle
2.5 Å
EMD-72466
3D View Gallery
Deposition: 02/09/2025
Map released: 24/06/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Eukaryotic translation initiation factor 2B
Fitted models: 9y3t

Deposition Authors: Dalwadi U, Croll T, Subramanian A, Lee DJ, Arthur C, Walter P, Frost A
Allosteric disordering of eIF2B regulates the integrated stress response.
Dalwadi U, Subramanian A, Deal A, Conrad JE, Nadjsombati T, Venkatesh M, Boone M, Egea PF, He L, Jain N, Lee DJ, Liu Y, Reineke LC, Saito K, Talledge N, Toutkoushian H, Le Vasseur M, Zappa F, de Groot RJ, Acosta-Alvear D, Arthur CP, Nunnari J, Marqusee S, Lawrence RE, Costa-Mattioli M, Crawford JJ, van Kuppeveld FJM, Croll TI, Walter P, Frost A
(2026) Nat Chem Biol
PUBMED: 42373951
DOI: doi:10.1038/s41589-026-02256-4
ISSN: 1552-4469
Grant Support: