EMD-72385
Cryo-EM structure of human VCP/p97-R89W mutant bound to CB-5083
EMD-72385
Single-particle2.58 Å
Deposition: 28/08/2025Map released: 29/04/2026
Last modified: 29/04/2026
Sample Organism:
Homo sapiens
Sample: VCP/p97 R89W mutant bound to CB-5083
Fitted models: 9y05
Deposition Authors: Lehman A
,
Ahmed S,
Mohajeri A ,
Yang GX,
Berezuk AM,
Mannar D ,
Cholak S,
Tuttle KS,
Bennett JT ,
Magno JA,
Hannibal M,
Kovacevic G,
Kuburovic V,
Lewis MES,
Moldovan O,
Nelson Z,
Raskin S,
Vandersteen AM,
Roach JC,
Subramaniam S,
Patel MS
Sample: VCP/p97 R89W mutant bound to CB-5083
Fitted models: 9y05
Deposition Authors: Lehman A
,
Ahmed S,
Mohajeri A ,
Yang GX,
Berezuk AM,
Mannar D ,
Cholak S,
Tuttle KS,
Bennett JT ,
Magno JA,
Hannibal M,
Kovacevic G,
Kuburovic V,
Lewis MES,
Moldovan O,
Nelson Z,
Raskin S,
Vandersteen AM,
Roach JC,
Subramaniam S,
Patel MS
Mutations in VCP cause Adams-Oliver syndrome with or without pulmonary hypertension.
Lehman A ,
Ahmed S,
Mohajeri A ,
Berezuk AM,
Mannar D ,
Cholak S,
Tuttle KS,
Bennett JT ,
Aparecida Magno J,
Hannibal M,
Kovacevic G,
Kuburovic V,
Suzanne Lewis ME,
Moldovan O,
Nelson Z,
Raskin S,
Vandersteen AM,
Roach JC,
Subramaniam S,
Patel MS
(2026) Genet Med , 102579 - 102579
,
Ahmed S,
Mohajeri A ,
Berezuk AM,
Mannar D ,
Cholak S,
Tuttle KS,
Bennett JT ,
Aparecida Magno J,
Hannibal M,
Kovacevic G,
Kuburovic V,
Suzanne Lewis ME,
Moldovan O,
Nelson Z,
Raskin S,
Vandersteen AM,
Roach JC,
Subramaniam S,
Patel MS
(2026) Genet Med , 102579 - 102579
Grant Support: