EMD-72294
Cryo-electron microscopy structure of PfRIPR bound to monoclonal antibodies RP.092 and RP.052
EMD-72294
Single-particle4.01 Å
Deposition: 22/08/2025Map released: 24/06/2026
Last modified: 26/08/2026
Sample Organism:
Mus musculus,
Plasmodium falciparum 3D7
Sample: A complex of RH5-interacting protein with monoclonal antibodies
Fitted models: 9q7c
Deposition Authors: Barrett JR, Ward AB
Sample: A complex of RH5-interacting protein with monoclonal antibodies
Fitted models: 9q7c
Deposition Authors: Barrett JR, Ward AB
Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection.
Williams BG 
,
Barrett JR,
Scott JB,
Rigby CA,
Cagiada M,
Quinkert D,
McHugh K,
Huhn A,
Burnap SA,
Gourjault C,
Byrne F,
Raghavan SSR,
Rodrigues A ,
Bergamaschi L,
Balzarotti B,
Watson S,
Miller N,
King LDW,
Donnellan FR,
Gladstone CA,
Paterson J,
Scalabrino S,
Silk SE,
Salkeld J,
Minassian AM,
Skinner K,
Struwe WB,
Deane CM,
Reece ST,
Ward AB,
Draper SJ
(2026) Immunity , 59 , 2106
,
Barrett JR,
Scott JB,
Rigby CA,
Cagiada M,
Quinkert D,
McHugh K,
Huhn A,
Burnap SA,
Gourjault C,
Byrne F,
Raghavan SSR,
Rodrigues A ,
Bergamaschi L,
Balzarotti B,
Watson S,
Miller N,
King LDW,
Donnellan FR,
Gladstone CA,
Paterson J,
Scalabrino S,
Silk SE,
Salkeld J,
Minassian AM,
Skinner K,
Struwe WB,
Deane CM,
Reece ST,
Ward AB,
Draper SJ
(2026) Immunity , 59 , 2106
Grant Support:
- Bill & Melinda Gates Foundation: (United States)