EMD-72277
Cryo-EM map of Plasmodium falciparum 20S proteasome bound to an asparagine-ethylenediamine based inhibitor TDI6245
EMD-72277
Single-particle2.86 Å
Deposition: 22/08/2025Map released: 29/07/2026
Last modified: 19/08/2026
Sample Organism:
Plasmodium falciparum
Sample: Complex of Plasmodium falciparum 20S with inhibitor TDI-6245
Fitted models: 9q6f
Deposition Authors: Hsu HC, Li H
Sample: Complex of Plasmodium falciparum 20S with inhibitor TDI-6245
Fitted models: 9q6f
Deposition Authors: Hsu HC, Li H
Structure-Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors.
Zhang H ,
Li D,
Hsu HC,
Vishwanatha A,
Zhan W,
Yukawa T,
Visone J,
Imaeda T,
Okamoto R,
Fajtova P,
Hara R,
Kawasaki M,
Sato K ,
Michino M ,
Garg S,
Kreutzfeld O,
Tumwebaze PK,
Orena S,
Okitwi M,
Aso K,
Cooper RA,
Rosenthal PJ,
Meinke PT ,
Foley M,
O'Donoghue AJ,
Li H ,
Kirkman LA,
Lin G
(2026) Acs Omega , 11 , 45549 - 45559
,
Li D,
Hsu HC,
Vishwanatha A,
Zhan W,
Yukawa T,
Visone J,
Imaeda T,
Okamoto R,
Fajtova P,
Hara R,
Kawasaki M,
Sato K ,
Michino M ,
Garg S,
Kreutzfeld O,
Tumwebaze PK,
Orena S,
Okitwi M,
Aso K,
Cooper RA,
Rosenthal PJ,
Meinke PT ,
Foley M,
O'Donoghue AJ,
Li H ,
Kirkman LA,
Lin G
(2026) Acs Omega , 11 , 45549 - 45559
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R21AI123794 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI143714 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI177635 (United States)