EMD-72244

Single-particle
3.12 Å
EMD-72244
3D View Gallery
Deposition: 21/08/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72244

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q60 summary report (pdf.gz) Map-9q60 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM Structure of human MDA5 disease-linked mutant T331I with dsRNA (one protein subunit on dsRNA)

EMD-72244

Single-particle
3.12 Å
EMD-72244
3D View Gallery
Deposition: 21/08/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Complex of human MDA5 disease-linked mutant T331I with dsRNA (one subunit on dsRNA)
Fitted models: 9q60

Deposition Authors: Xu L, Chung K, Pyle A, Pyle A

Unraveling the molecular basis for MDA5 T331I disease-linked mutation
Xu L, Chung K, Guo R, Pan A, Pyle AM
To Be Published
Grant Support: