EMD-72243

Single-particle
3.21 Å
EMD-72243
3D View Gallery
Deposition: 21/08/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72243

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q5w summary report (pdf.gz) Map-9q5w FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM Structure of human MDA5 T331I mutant in complex with dsRNA

EMD-72243

Single-particle
3.21 Å
EMD-72243
3D View Gallery
Deposition: 21/08/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Complex of human MDA5 T331I mutant with dsRNA
Fitted models: 9q5w

Deposition Authors: Xu L, Chung K, Pyle A, Pyle A

Unraveling the molecular basis for MDA5 T331I disease-linked mutation
Xu L, Chung K, Guo R, Pan A, Pyle AM
To Be Published
Grant Support: