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EMD-72178

Single-particle
3.2 Å
EMD-72178
3D View Gallery
Deposition: 15/08/2025
Map released: 14/01/2026
Last modified: 14/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72178
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9q33 summary report (pdf.gz) Map and 9q33 FULL report (pdf.gz)
EMICSS annotations (xml)

Cereblon Ternary Complex with Blimp1 and compound 5

EMD-72178

Single-particle
3.2 Å
EMD-72178
3D View Gallery
Deposition: 15/08/2025
Map released: 14/01/2026
Last modified: 14/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cereblon Ternary Complex with Blimp1 and compound 5
Fitted models: 9q33

Deposition Authors: Watson ER, Lander GC
Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders.
Simmons BJ, Groocock L, Moreno J, Peters DS, Hughes ME, Veeravalli V, Crawford JM, Chalkley M, Griffith M, Plooster M, Hu B, Gamez J, Leisten J, Barnes MJ, Chinn J, Deb G, Modi H, Katepalli M, Weiss D, Won W, Sun Z, Yu S, Reid C, Donnell AF, Li L, Watson ER, Perrin-Ninkovic S, Shi L, Narla RK, Zapf CW, Bence N, Lopez-Girona A, Riggs JR
(2025) J Med Chem , 68 , 25385 - 25402
PUBMED: 41284831
DOI: doi:10.1021/acs.jmedchem.5c02363
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: