EMD-72086

Single-particle
3.15 Å
EMD-72086
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Deposition: 12/08/2025
Map released: 15/10/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72086
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9q03 summary report (pdf.gz) Map and 9q03 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of ternary complex BCL6-CRBN-DDB1 with BCL6-760 (LDD, local refined)

EMD-72086

Single-particle
3.15 Å
EMD-72086
3D View Gallery
Deposition: 12/08/2025
Map released: 15/10/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ternary complex of BCL6-CRBN-DDB1 with an LDD BCL6-760
Fitted models: 9q03

Deposition Authors: Zhu J , Fang W, Pagarigan B
Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760.
Shunatona HP , Holmberg Douglas N, Rhodes J, Thomas W, Da Silva D, Gamez J, Groza M, Christoforou A, Zhu J , Johnson S, Dodd D, Huang D, Griffin J, Miseo G, Whitefield B, Weiss D, Rader J, Kuzu E, Leisten J, Del Rosario J, Shi L , Matyskiela M, Chamberlain PP , Belmont P, Alexander M, Zapf CW, Groocock L, Mortensen DS
(2025) J Med Chem , 68 , 21502 - 21519
PUBMED: 41055242
DOI: doi:10.1021/acs.jmedchem.5c01645
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: