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EMD-72038

Single-particle
3.1 Å
EMD-72038
3D View Gallery
Deposition: 08/08/2025
Map released: 17/09/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72038
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9pyw summary report (pdf.gz) Map and 9pyw FULL report (pdf.gz)
EMICSS annotations (xml)

SARS-CoV-2 nsp7, nsp8 and nsp12 bound to a primer-template pair with incorporated ara-UMP

EMD-72038

Single-particle
3.1 Å
EMD-72038
3D View Gallery
Deposition: 08/08/2025
Map released: 17/09/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, synthetic construct
Sample: SARS-CoV-2 nsp7, nsp8 and nsp12 bound to a primer-template pair with incorporated ara-UMP
Fitted models: 9pyw

Deposition Authors: Xiao Z , Kirchdeorfer RN
The 2'-endo conformation of arabinose-CTP and arabinose-UTP inhibit viral polymerases by inducing long pauses.
Xiao Z , Das A, Jain A, Anderson TK , Cameron CE, Arnold JJ, Dulin D , Kirchdoerfer RN
(2025) bioRxiv
PUBMED: 40909592
DOI: doi:10.1101/2025.08.26.672356
ISSN: 2692-8205