EMD-71894

Single-particle
3.89 Å
EMD-71894
3D View Gallery
Deposition: 03/08/2025
Map released: 10/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71894
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9pvo summary report (pdf.gz) Map and 9pvo FULL report (pdf.gz)
EMICSS annotations (xml)

Novel site 1 interaction of the IR/Ins-AC-S2 complex

EMD-71894

Single-particle
3.89 Å
EMD-71894
3D View Gallery
Deposition: 03/08/2025
Map released: 10/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Half model of the insulin receptor-A isoform complexed with Ins-AC-S2.
Fitted models: 9pvo

Deposition Authors: Vogel A, Blakely A, Hill CP
Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands S961 and Ins-AC-S2.
Vogel A, Blakely A, Dao Y, Lin NP, Chou D, Hill CP
(2026) Nat Commun , 17
PUBMED: 42265100
DOI: doi:10.1038/s41467-026-73851-1
ISSN: 2041-1723