EMD-71833
Cryo-EM structure of the DCAF11 E3 ligase bound to the DDX18 helicase mediated by GSH-M12 (DDX18 local refinement)
EMD-71833
Single-particle2.38 Å
Deposition: 27/07/2025Map released: 01/07/2026
Last modified: 07/10/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex of the E3 ligase DCAF11 and the helicase DDX18 mediated by GSH-M12
Deposition Authors: Wachter F
,
Jin CY ,
Yoon H ,
Ebert BL ,
Fischer ES
Sample: Ternary complex of the E3 ligase DCAF11 and the helicase DDX18 mediated by GSH-M12
Deposition Authors: Wachter F
,
Jin CY ,
Yoon H ,
Ebert BL ,
Fischer ES
DCAF11-dependent molecular glue degrader activated by glutathionylation.
Yoon H ,
Wachter F ,
Barrett KA,
Jin C,
Rodriguez-Pohnlein A,
Rutter JC ,
Lumpkin RJ,
Metivier RJ,
Donovan KA,
Baek K ,
Jiang Y,
Lee M,
Kalis RW ,
Che J,
Xiong Y ,
Fischer ES ,
Ebert BL
(2026) Nature , 657 , 1045 - 1052
,
Wachter F ,
Barrett KA,
Jin C,
Rodriguez-Pohnlein A,
Rutter JC ,
Lumpkin RJ,
Metivier RJ,
Donovan KA,
Baek K ,
Jiang Y,
Lee M,
Kalis RW ,
Che J,
Xiong Y ,
Fischer ES ,
Ebert BL
(2026) Nature , 657 , 1045 - 1052
Grant Support: