EMD-71783
Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149
EMD-71783
Single-particle3.29 Å
Deposition: 22/07/2025Map released: 20/08/2025
Last modified: 25/03/2026
Sample Organism:
Homo sapiens
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149
Fitted models: 9pqd
Deposition Authors: Srinivasan K
,
Wu Y,
Billesboelle C,
Kim JY ,
Manglik A,
Shoichet BK
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149
Fitted models: 9pqd
Deposition Authors: Srinivasan K
,
Wu Y,
Billesboelle C,
Kim JY ,
Manglik A,
Shoichet BK
Large Library Docking for Polypharmacology.
Wu Y,
Vigneron S,
Braz J,
Srinivasan K ,
Fink EA ,
Huang XP,
Xu X,
Huebner H ,
Kim JY ,
Wang J ,
Pfeiffer T ,
Sakamoto K ,
Radchenko DS ,
Rodriguiz RM,
Moroz YS ,
Irwin JJ,
Gmeiner P ,
Billesboelle C,
Roth BL ,
Basbaum AI,
Manglik A,
Wetsel WC,
Shoichet BK
(2026) J Med Chem , 69 , 6210 - 6229
,
Fink EA ,
Huang XP,
Xu X,
Huebner H ,
Kim JY ,
Wang J ,
Pfeiffer T ,
Sakamoto K ,
Radchenko DS ,
Rodriguiz RM,
Moroz YS ,
Irwin JJ,
Gmeiner P ,
Billesboelle C,
Roth BL ,
Basbaum AI,
Manglik A,
Wetsel WC,
Shoichet BK
(2026) J Med Chem , 69 , 6210 - 6229
Grant Support:
- Defense Advanced Research Projects Agency (DARPA): HR0011-19-2-0020 (United States)
- Department of Health & Human Services (HHS): 1AY1AX000035 (United States)