EMD-71775

Single-particle
3.34 Å
EMD-71775
3D View Gallery
Deposition: 21/07/2025
Map released: 04/03/2026
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71775
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ppq summary report (pdf.gz) Map and 9ppq FULL report (pdf.gz)
EMICSS annotations (xml)

Locally-refined Mu-Opioid Receptor bound with novel compound 0505

EMD-71775

Single-particle
3.34 Å
EMD-71775
3D View Gallery
Deposition: 21/07/2025
Map released: 04/03/2026
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Active-state Mu-opioid receptor fused with miniG protein, bound with GBetaGamma, scFv16, and compound 0505
Fitted models: 9ppq

Deposition Authors: Kim JY , Wu Y, Manglik A, Shoichet BK
Large Library Docking for Polypharmacology.
Wu Y, Vigneron S, Braz J, Srinivasan K , Fink EA , Huang XP, Xu X, Huebner H , Kim JY , Wang J , Pfeiffer T , Sakamoto K , Radchenko DS , Rodriguiz RM, Moroz YS , Irwin JJ, Gmeiner P , Billesboelle C, Roth BL , Basbaum AI, Manglik A, Wetsel WC, Shoichet BK
(2026) J Med Chem
PUBMED: 41712624
DOI: doi:10.1021/acs.jmedchem.5c03810
ISSN: 0022-2623
ASTM: JMCMAR