EMD-71719
Structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905)
EMD-71719
Single-particle2.8 Å
Deposition: 15/07/2025Map released: 30/07/2025
Last modified: 30/09/2026
Sample Organism:
Homo sapiens,
Mus musculus
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound 4905.
Fitted models: 9plo
Deposition Authors: Srinivasan K, Xu X, Mailhot O, Manglik A
,
Shoichet B
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound 4905.
Fitted models: 9plo
Deposition Authors: Srinivasan K, Xu X, Mailhot O, Manglik A
,
Shoichet B
Development of a random background to understand ligand optimization.
Xu X,
Mailhot O,
Correy GJ,
Huang XP,
Braz JM ,
Shi D ,
Srinivasan K,
Zielinski K,
Holota Y ,
Kuziv Y ,
Iliopoulos-Tsoutsouvas C,
Levinzon ND,
Doruk YU,
Rachman MM,
Diolaiti ME ,
Stevens MGV,
Liu F ,
Holland KL,
Hubner H,
Wang J ,
Wu Y,
Ashworth A ,
Makriyannis A ,
Zhang Y,
Moroz YS ,
Gmeiner P ,
Abel R,
Manglik A ,
Basbaum AI ,
Roth BL ,
Fraser JS ,
Shoichet BK
(2026) Nature
,
Shi D ,
Srinivasan K,
Zielinski K,
Holota Y ,
Kuziv Y ,
Iliopoulos-Tsoutsouvas C,
Levinzon ND,
Doruk YU,
Rachman MM,
Diolaiti ME ,
Stevens MGV,
Liu F ,
Holland KL,
Hubner H,
Wang J ,
Wu Y,
Ashworth A ,
Makriyannis A ,
Zhang Y,
Moroz YS ,
Gmeiner P ,
Abel R,
Manglik A ,
Basbaum AI ,
Roth BL ,
Fraser JS ,
Shoichet BK
(2026) Nature
Grant Support:
- Defense Advanced Research Projects Agency (DARPA): (United States)