EMD-71718

Single-particle
2.8 Å
EMD-71718
3D View Gallery
Deposition: 15/07/2025
Map released: 20/08/2025
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71718
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9pln summary report (pdf.gz) Map and 9pln FULL report (pdf.gz)
EMICSS annotations (xml)

Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905)

EMD-71718

Single-particle
2.8 Å
EMD-71718
3D View Gallery
Deposition: 15/07/2025
Map released: 20/08/2025
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound 4905.
Fitted models: 9pln

Deposition Authors: Srinivasan K , Xu X , Mailhot O , Manglik A , Shoichet B
Toward a Random Background for Ligand Optimization.
Xu X , Mailhot O , Correy GJ, Huang XP, Braz J, Shi D, Srinivasan K , Zielinski K, Holota Y, Kuziv Y, Tsoutsouvas C, Levinzon N, Doruk YU, Rachman M, Diolaiti M, Stevens M, Liu F, Holland K, Hubner H, Wang J, Wu Y, Ashworth A, Makriyannis A, Zhang Y, Moroz Y, Gmeiner P, Abel R, Manglik A , Basbaum AI, Roth BL, Fraser JS, Shoichet BK
(2026) bioRxiv
PUBMED: 42182464
DOI: doi:10.64898/2026.05.10.724162
ISSN: 2692-8205
Grant Support: