EMD-71714
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened T2a local refinement map from cryoSPARC)
EMD-71714
Single-particle3.23 Å
Deposition: 15/07/2025Map released: 29/07/2026
Last modified: 29/07/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: Wild-type human CFTR solubilized in digitonin and cholesterol-hemisuccinate plus T2a nanobody in the presence of 2 mM MgATP
Deposition Authors: Hunt JF
,
Paige AS ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Rich Z
Sample: Wild-type human CFTR solubilized in digitonin and cholesterol-hemisuccinate plus T2a nanobody in the presence of 2 mM MgATP
Deposition Authors: Hunt JF
,
Paige AS ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Rich Z
Nanobody-Driven Stabilization Synergistically Rescues F508del-CFTR and Reveals an Alternative Active State of the Channel
Hunt FJ,
Paige AS ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Urbatsch IL,
Lukacs G
To Be Published
,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Urbatsch IL,
Lukacs G
To Be Published
Grant Support: