EMD-71664

Single-particle
3.01 Å
EMD-71664
3D View Gallery
Deposition: 10/07/2025
Map released: 03/06/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71664

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9pie summary report (pdf.gz) Map-9pie FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human NCC with chlorthalidone (C2)

EMD-71664

Single-particle
3.01 Å
EMD-71664
3D View Gallery
Deposition: 10/07/2025
Map released: 03/06/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Danio rerio
Sample: NCC-chlorthalidone complex
Fitted models: 9pie

Deposition Authors: Zhang J , Feng L , Feng L
Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter.
Lee CL , Zhang J , Feng L
(2025) Nat Commun , 16 , 7740 - 7740
PUBMED: 40830368
DOI: doi:10.1038/s41467-025-62714-w
ISSN: 2041-1723