EMD-71253

Single-particle
3.27 Å
EMD-71253
3D View Gallery
Deposition: 14/06/2025
Map released: 07/01/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71253

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9p3s summary report (pdf.gz) Map-9p3s FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Zebrafish TRPM5 D797N mutant with 5mM calcium and 0.5mM CBTA

EMD-71253

Single-particle
3.27 Å
EMD-71253
3D View Gallery
Deposition: 14/06/2025
Map released: 07/01/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Danio rerio
Sample: zebrafish TRPM5 D797N mutant in GDN detergent with 5mM calcium and 0.5mM CBTA
Fitted models: 9p3s

Deposition Authors: Ruan Z , Du J , Lu W
A single allosteric site merges activation, modulation and inhibition in TRPM5.
Ruan Z , Lee J, Li Y, Orozco IJ, Du J , Lu W
(2026) Nat Chem Biol , 22 , 402 - 410
PUBMED: 41491833
DOI: doi:10.1038/s41589-025-02097-7
ISSN: 1552-4469