Electron Microscopy Data Bank

EMD-71244

Single-particle
3.1 Å

3D View Gallery

Deposition: 14/06/2025
Map released: 07/01/2026
Last modified: 18/03/2026

Overview 3D View Sample Experiment Validation Additional data Links

EMD-71244

The consensus map of zebrafish TRPM5 with 1mM EDTA and 0.5mM CBTA

EMD-71244

Single-particle
3.1 Å
EMD-71244

3D View Gallery

Deposition: 14/06/2025
Map released: 07/01/2026
Last modified: 18/03/2026

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Danio rerio
Sample: zebrafish TRPM5 in GDN detergent with 1mM EDTA and 0.5mM CBTA

Deposition Authors: Ruan Z , Du J , Lu W

A single allosteric site merges activation, modulation and inhibition in TRPM5.

Ruan Z , Lee J , Li Y, Orozco IJ, Du J , Lu W
(2026) Nat Chem Biol , 22 , 402 - 410

PUBMED: 41491833
DOI: doi:10.1038/s41589-025-02097-7
ISSN: 1552-4469

Grant Support:

National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R00NS128258 (United States)
National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): R01HL153219 (United States)
National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01NS112363 (United States)
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM138321 (United States)
National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01NS111031 (United States)
National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01NS129804 (United States)

EMD-71244

EMD-71244

Archive Files (Depositor)

Validation (wwPDB)

EMDB Annotations

EMDB Files

The consensus map of zebrafish TRPM5 with 1mM EDTA and 0.5mM CBTA

EMD-71244