EMD-71128

Single-particle
2.9 Å
EMD-71128
3D View Gallery
Deposition: 10/06/2025
Map released: 24/12/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71128

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9p1m summary report (pdf.gz) Map-9p1m FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of CD73 in complex with antibody Sym024

EMD-71128

Single-particle
2.9 Å
EMD-71128
3D View Gallery
Deposition: 10/06/2025
Map released: 24/12/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: CD73 dimer bound to antibody Sym024
Fitted models: 9p1m

Deposition Authors: Armbruster E , Bansia H , Des Georges A
Sym024 Interacts with a Unique Epitope on the CD73 Homodimer, Favoring Effective Bivalent Binding to Improve Anti-PD-1 Therapy.
Jakobsen JS , Grandal MM , Hansen RW , Bansia H , Armbruster E , Theret I , Skartved NJO , Hald R , Melander MC , Worsaae A , Riva M , Reckzeh K , Vuillard L , Lantto J , des Georges A , Frohlich C
(2026) Clin.Cancer Res. , 32 , 1120 - 1135
PUBMED: 41511395
DOI: doi:10.1158/1078-0432.CCR-25-2406
ISSN: 1078-0432
Grant Support: