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EMD-71090

Single-particle
3.7 Å
EMD-71090
3D View Gallery
Deposition: 07/06/2025
Map released: 27/08/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71090
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9p0x summary report (pdf.gz) Map and 9p0x FULL report (pdf.gz)
EMICSS annotations (xml)

Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab (nanodisc-subtracted)

EMD-71090

Single-particle
3.7 Å
EMD-71090
3D View Gallery
Deposition: 07/06/2025
Map released: 27/08/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus, Escherichia coli
Sample: Complex of factor VIIa, XK1 and the Fab fragment of antibody 10H10, all bound to tissue factor embedded in a nanodisc membrane bilayer.
Fitted models: 9p0x

Deposition Authors: Photenhauer AL , Sedzro JC , Ohi MD , Morrissey JH
Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism.
Sedzro JC , Photenhauer AL , Birkle F , Meze K , Mortenson A , Duckworth C , Wen PC , Kearns S , Cianfrocco MA , Tajkhorshid E , Ohi MD , Morrissey JH
(2025) Blood , 146 , 2833 - 2842
PUBMED: 40811856
DOI: doi:10.1182/blood.2025029430
ISSN: 1528-0020