EMD-71090
Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab (nanodisc-subtracted)
EMD-71090
Single-particle3.7 Å
Deposition: 07/06/2025Map released: 27/08/2025
Last modified: 17/12/2025
Sample Organism:
Homo sapiens,
Mus musculus,
Escherichia coli
Sample: Complex of factor VIIa, XK1 and the Fab fragment of antibody 10H10, all bound to tissue factor embedded in a nanodisc membrane bilayer.
Fitted models: 9p0x
Deposition Authors: Photenhauer AL
,
Sedzro JC ,
Ohi MD ,
Morrissey JH
Sample: Complex of factor VIIa, XK1 and the Fab fragment of antibody 10H10, all bound to tissue factor embedded in a nanodisc membrane bilayer.
Fitted models: 9p0x
Deposition Authors: Photenhauer AL
,
Sedzro JC ,
Ohi MD ,
Morrissey JH
Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism.
Sedzro JC ,
Photenhauer AL ,
Birkle F ,
Meze K ,
Mortenson A ,
Duckworth C ,
Wen PC ,
Kearns S ,
Cianfrocco MA ,
Tajkhorshid E ,
Ohi MD ,
Morrissey JH
(2025) Blood , 146 , 2833 - 2842
,
Photenhauer AL ,
Birkle F ,
Meze K ,
Mortenson A ,
Duckworth C ,
Wen PC ,
Kearns S ,
Cianfrocco MA ,
Tajkhorshid E ,
Ohi MD ,
Morrissey JH
(2025) Blood , 146 , 2833 - 2842
Grant Support:
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): R35 HL135823 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): R35 HL171334 (United States)
- National Institutes of Health/Office of the Director: S10OD030275 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R24 GM145965 (United States)
- American Heart Association: N028347 (United States)