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EMD-71062
Cryo-EM structure of apo S. Mansoni p97
EMD-71062
Single-particle2.72 Å
Deposition: 06/06/2025Map released: 13/08/2025
Last modified: 10/09/2025
Sample Organism:
Schistosoma mansoni
Sample: Homohexamer of p97
Fitted models: 9p00
Deposition Authors: Stephens DR
,
Han Y
,
Chen Z
,
Collins JJ,
Fung HYJ
Sample: Homohexamer of p97
Fitted models: 9p00
Deposition Authors: Stephens DR
,
Han Y
,
Chen Z
,
Collins JJ,
Fung HYJ
A genome-scale drug discovery pipeline uncovers therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni.
Stephens DR
,
Fung HYJ
,
Han Y
,
Liang J,
Chen Z
,
Ready J
,
Collins 3rd JJ
(2025) PNAS , 122 , e2505710122 - e2505710122
,
Fung HYJ
,
Han Y
,
Liang J,
Chen Z
,
Ready J
,
Collins 3rd JJ
(2025) PNAS , 122 , e2505710122 - e2505710122
Grant Support:
- Cancer Prevention and Research Institute of Texas (CPRIT): RP220582 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI167967 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI150776 (United States)
- Welch Foundation: I-1948-20240404 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)
