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EMD-70961

Single-particle
2.85 Å
EMD-70961
3D View Gallery
Deposition: 03/06/2025
Map released: 13/08/2025
Last modified: 10/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70961
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ox9 summary report (pdf.gz) Map and 9ox9 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of S. Mansoni p97 bound to CB-5083

EMD-70961

Single-particle
2.85 Å
EMD-70961
3D View Gallery
Deposition: 03/06/2025
Map released: 13/08/2025
Last modified: 10/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Schistosoma mansoni
Sample: p97 Homohexamer bound to inhibitor CB-5083
Fitted models: 9ox9

Deposition Authors: Stephens DR , Han Y , Chen Z , Collins JJ, Fung HYJ
A genome-scale drug discovery pipeline uncovers therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni.
Stephens DR , Fung HYJ , Han Y , Liang J, Chen Z , Ready J , Collins 3rd JJ
(2025) PNAS , 122 , e2505710122 - e2505710122
PUBMED: 40880532
DOI: doi:10.1073/pnas.2505710122
ISSN: 1091-6490
ASTM: PNASA6