EMD-70926

Single-particle
3.1 Å
EMD-70926
3D View Gallery
Deposition: 01/06/2025
Map released: 10/06/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70926

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ovy summary report (pdf.gz) Map-9ovy FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human PRMT5:MEP50 in complex with SAH and compounds 16-19F and HJL-1

EMD-70926

Single-particle
3.1 Å
EMD-70926
3D View Gallery
Deposition: 01/06/2025
Map released: 10/06/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of human PRMT5:MEP50 in complex with SAH and compounds 16-19F and HJL-1
Fitted models: 9ovy

Deposition Authors: Xu X , Chi Z , Jiang W , Li C
Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment.
Chi Z , Xu X , Shen Z, Deng X, Elzey BD, Li C , Jiang W , Hu CD
(2026) J Enzyme Inhib Med Chem , 41 , 2727844 - 2727844
PUBMED: 42710907
DOI: doi:10.1080/14756366.2026.2727844
ISSN: 1475-6374