EMD-70912
Heteromeric GluA1/A2 in the inactive state, composite map of LBD-TMD
EMD-70912
Single-particle3.43 Å
Deposition: 31/05/2025Map released: 08/04/2026
Last modified: 20/05/2026
Sample Organism:
Rattus norvegicus
Sample: Heteromeric GluA1A2 with competitive antagonist ZK
Fitted models: 9ovt
Deposition Authors: Yen LY, Sobolevsky AI
,
Newton TP ,
Gangwar SP
Sample: Heteromeric GluA1A2 with competitive antagonist ZK
Fitted models: 9ovt
Deposition Authors: Yen LY, Sobolevsky AI
,
Newton TP ,
Gangwar SP
Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor core.
Yen LY,
Newton TP ,
Yelshanskaya MV,
Aktolun M ,
Gangwar SP ,
Clausen RP,
Kurnikova MG ,
Sobolevsky AI
(2026) Nat Commun , 17
,
Yelshanskaya MV,
Aktolun M ,
Gangwar SP ,
Clausen RP,
Kurnikova MG ,
Sobolevsky AI
(2026) Nat Commun , 17
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): U24 GM129539 (United States)
- Simons Foundation: SF349247 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): U24 GM129541 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): F31NS132554 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NS139087 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NS083660 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NS107253 (United States)
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): AR078814 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA206573 (United States)