EMD-70870

Composite map
Single-particle
2.97 Å
EMD-70870
3D View Gallery
Deposition: 28/05/2025
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70870
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9oul summary report (pdf.gz) Map and 9oul FULL report (pdf.gz)
EMICSS annotations (xml)

DDB1-CRBN with Ikaros(ZF2), SB-405483, and DEG-47: composite map and model submission

EMD-70870

Composite map
Single-particle
2.97 Å
EMD-70870
3D View Gallery
Deposition: 28/05/2025
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DDB1(BPB deleted)-CRBN complex with ikaros ZF2-3, SB-405483, and DEG-47 was incubated for 30 minutes and then plunge frozen over 1.2/1.3 UltrAufoil
Fitted models: 9oul

Deposition Authors: Rizvi Z , Lander GC
Identification of an allosteric site on the E3 ligase adapter cereblon.
Dippon VN , Rizvi Z , Choudhry AE, Chung CW , Alkuraya IF, Xu W , Tao XB , Jurewicz AJ, Schneck JL , Chen W, Curnutt NM , Kabir F, Chan KH , Queisser MA , Musetti C, Dai H, Lander GC , Benowitz AB , Woo CM
(2026) Nature
PUBMED: 41565821
DOI: doi:10.1038/s41586-025-09994-w
ISSN: 1476-4687
ASTM: NATUAS