EMD-70826

Single-particle
3.54 Å
EMD-70826
3D View Gallery
Deposition: 26/05/2025
Map released: 03/12/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70826

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ot6 summary report (pdf.gz) Map-9ot6 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the PI4KA complex bound to an EFR3 interfering nanobody (F3IN)

EMD-70826

Single-particle
3.54 Å
EMD-70826
3D View Gallery
Deposition: 26/05/2025
Map released: 03/12/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Dimer of heterotetramers of PI4KA,TTC7B,FAM126A, and EFR3 interfering nanobody (F3IN)
Fitted models: 9ot6

Deposition Authors: Shaw AL , Suresh S, Yip CK , Burke JE
Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.
Suresh S, Shaw AL , Akintola DK, Lunke M, Doerr S , Rohilla P, Balla T, Yip CK , Hansen SD, Cobb JA, Burke JE
(2025) J Biol Chem , 301 , 110886 - 110886
PUBMED: 41197736
DOI: doi:10.1016/j.jbc.2025.110886
ISSN: 1083-351X
ASTM: JBCHA3