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EMD-70812
Tetrameric POLQ Helicase-like Domain Bound to Cmpd 19, a Small-Molecule ATPase Inhibitor and Drug Candidate Analog
EMD-70812
Single-particle2.67 Å
Deposition: 26/05/2025Map released: 17/09/2025
Last modified: 01/10/2025
Sample Organism:
Homo sapiens
Sample: Polymerase theta N-terminal domain in complex with ATPase inhibitor compound
Fitted models: 9osw
Deposition Authors: Zahn KE
,
Scapin G
Sample: Polymerase theta N-terminal domain in complex with ATPase inhibitor compound
Fitted models: 9osw
Deposition Authors: Zahn KE
,
Scapin G
The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Pol theta ATPase Inhibitor.
Mochirian P,
Papp R,
Mathieu MC,
Ferraro GB,
Dietrich E,
Liu B,
Bendahan D,
Perryman AL,
Surprenant S,
Fournier S,
Barzili BL,
Bonneau-Fortin A,
Yin SY,
Leclaire ME,
Patel C,
Poirier H,
Save S,
Mathieu Y,
Morin N,
Godbout C,
Burston HE,
Zahn KE ,
Attia MA,
Pinter T,
Barabe F,
Parikh P,
Jagani C,
Kang G,
Scapin G ,
Mamane Y,
Sfeir A,
Mader P ,
Sicheri F ,
Zimmermann M,
Roulston A,
Morris SJ,
Black WC ,
Gallant M
(2025) J Med Chem , 68 , 19726 - 19745
,
Attia MA,
Pinter T,
Barabe F,
Parikh P,
Jagani C,
Kang G,
Scapin G ,
Mamane Y,
Sfeir A,
Mader P ,
Sicheri F ,
Zimmermann M,
Roulston A,
Morris SJ,
Black WC ,
Gallant M
(2025) J Med Chem , 68 , 19726 - 19745
Grant Support: