EMD-70791
Cryo-EM structure of the DDB1/CRBN-MRT-5702-G3BP2 ternary complex
EMD-70791
Single-particle2.5 Å
Deposition: 23/05/2025Map released: 28/01/2026
Last modified: 01/04/2026
Sample Organism:
Homo sapiens
Sample: DDB1/CRBN-MRT-5702-G3BP2 ternary complex
Fitted models: 9os2
Deposition Authors: Quan C
,
Petzold G ,
Gainza P ,
Tsai J,
Bunker RD ,
Wiedmer L,
Donckele EJ
Sample: DDB1/CRBN-MRT-5702-G3BP2 ternary complex
Fitted models: 9os2
Deposition Authors: Quan C
,
Petzold G ,
Gainza P ,
Tsai J,
Bunker RD ,
Wiedmer L,
Donckele EJ
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.
Annunziato S,
Quan C ,
Donckele EJ,
Lamberto I,
Bunker RD ,
Zlotosch M,
Schwander L,
Murthy A,
Wiedmer L,
Staehly C,
Matysik M ,
Gilberto S ,
Kapsitidou D,
Wible D,
De Donatis GM,
Trenh P ,
SriRamaratnam R,
Strande V,
Lieberherr R ,
Lyon D,
Steiner D,
Silva J,
Almeida R,
Dolgikh E,
DeMarco B,
Tsai J,
Sadok A ,
Zarayskiy V,
Walter M,
Tiedt R,
Lumb KJ ,
Bonenfant D,
Fasching B,
Castle JC,
Townson SA ,
Gainza P ,
Petzold G
(2026) Nat Struct Mol Biol , 33 , 479 - 487
,
Donckele EJ,
Lamberto I,
Bunker RD ,
Zlotosch M,
Schwander L,
Murthy A,
Wiedmer L,
Staehly C,
Matysik M ,
Gilberto S ,
Kapsitidou D,
Wible D,
De Donatis GM,
Trenh P ,
SriRamaratnam R,
Strande V,
Lieberherr R ,
Lyon D,
Steiner D,
Silva J,
Almeida R,
Dolgikh E,
DeMarco B,
Tsai J,
Sadok A ,
Zarayskiy V,
Walter M,
Tiedt R,
Lumb KJ ,
Bonenfant D,
Fasching B,
Castle JC,
Townson SA ,
Gainza P ,
Petzold G
(2026) Nat Struct Mol Biol , 33 , 479 - 487
Grant Support: