EMD-70789

Single-particle
2.9 Å
EMD-70789
3D View Gallery
Deposition: 23/05/2025
Map released: 19/11/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70789

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

DDB1-CRBN-CK1a with lenalidomide and SB-405483 (Focused map)

EMD-70789

Single-particle
2.9 Å
EMD-70789
3D View Gallery
Deposition: 23/05/2025
Map released: 19/11/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DDB1(BPB deleted)-CRBN complex with Casein kinase 1 alpha, lenalidomide, and SB-405483

Deposition Authors: Rizvi Z , Lander GC
Identification of an allosteric site on the E3 ligase adapter cereblon.
Dippon VN , Rizvi Z , Choudhry AE, Chung CW , Alkuraya IF, Xu W , Tao XB , Jurewicz AJ, Schneck JL , Chen W, Curnutt NM , Kabir F, Chan KH , Queisser MA , Musetti C, Dai H, Lander GC , Benowitz AB , Woo CM
(2026) Nature , 651 , 482 - 490
PUBMED: 41565821
DOI: doi:10.1038/s41586-025-09994-w
ISSN: 1476-4687
ASTM: NATUAS